Ageritin, a Ribotoxin from Poplar Mushroom ( Agrocybe aegerita) with Defensive and Antiproliferative Activities.
Identifieur interne : 000B44 ( Main/Exploration ); précédent : 000B43; suivant : 000B45Ageritin, a Ribotoxin from Poplar Mushroom ( Agrocybe aegerita) with Defensive and Antiproliferative Activities.
Auteurs : Lucía Citores [Espagne] ; Sara Ragucci [Italie] ; José M. Ferreras [Espagne] ; Antimo Di Maro [Italie] ; Rosario Iglesias [Espagne]Source :
- ACS chemical biology [ 1554-8937 ] ; 2019.
Descripteurs français
- KwdFr :
- Agrocybe (composition chimique), Anti-infectieux (pharmacologie), Cytotoxines (pharmacologie), Humains (MeSH), Lignée cellulaire tumorale (MeSH), Micrococcus (effets des médicaments et des substances chimiques), Prolifération cellulaire (effets des médicaments et des substances chimiques), Ribonucléases (isolement et purification), Ribonucléases (pharmacologie), Tests de criblage d'agents antitumoraux (MeSH), Tests de sensibilité microbienne (MeSH), Virus de la mosaïque du tabac (effets des médicaments et des substances chimiques).
- MESH :
- composition chimique : Agrocybe.
- effets des médicaments et des substances chimiques : Micrococcus, Prolifération cellulaire, Virus de la mosaïque du tabac.
- isolement et purification : Ribonucléases.
- pharmacologie : Anti-infectieux, Cytotoxines, Ribonucléases.
- Humains, Lignée cellulaire tumorale, Tests de criblage d'agents antitumoraux, Tests de sensibilité microbienne.
English descriptors
- KwdEn :
- Agrocybe (chemistry), Anti-Infective Agents (pharmacology), Cell Line, Tumor (MeSH), Cell Proliferation (drug effects), Cytotoxins (pharmacology), Drug Screening Assays, Antitumor (MeSH), Humans (MeSH), Microbial Sensitivity Tests (MeSH), Micrococcus (drug effects), Ribonucleases (isolation & purification), Ribonucleases (pharmacology), Tobacco Mosaic Virus (drug effects).
- MESH :
- chemical , isolation & purification : Ribonucleases.
- chemical , pharmacology : Anti-Infective Agents, Cytotoxins, Ribonucleases.
- chemistry : Agrocybe.
- drug effects : Cell Proliferation, Micrococcus, Tobacco Mosaic Virus.
- Cell Line, Tumor, Drug Screening Assays, Antitumor, Humans, Microbial Sensitivity Tests.
Abstract
Ribotoxins make up a group of extracellular rRNA endoribonucleases produced by ascomycetes that display cytotoxicity toward animal cells, having been proposed as insecticidal agents. Recently, the ribotoxin Ageritin has been isolated from the basidiomycetes Agrocybe aegerita (poplar mushroom), suggesting that ribotoxins are widely distributed among fungi. To gain insights into the protective properties of Ageritin against pathogens and its putative biotechnological applications, we have tested several biological activities of Ageritin, comparing them with those of the well-known ribotoxin α-sarcin, and we found that Ageritin displayed, in addition to the already reported activities, (i) antibacterial activity against Micrococcus lysodeikticus, (ii) activity against the tobacco mosaic virus RNA, (iii) endonuclease activity against a supercoiled plasmid, (iv) nuclease activity against genomic DNA, (v) cytotoxicity to COLO 320, HeLa, and Raji cells by promoting apoptosis, and (vi) antifungal activity against the green mold Penicillium digitatum. Therefore, Ageritin and α-sarcin can induce resistance not only to insects but also to viruses, bacteria, and fungi. The multiple biological activities of Ageritin could be exploited to improve resistance to different pathogens by engineering transgenic plants. Furthermore, the induction of cell death by different mechanisms turns these ribotoxins into useful tools for cancer therapy.
DOI: 10.1021/acschembio.9b00291
PubMed: 31136705
Affiliations:
Links toward previous steps (curation, corpus...)
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Pharmaceutical Sciences and Technologies , University of Campania "Luigi Vanvitelli" , I-81100 Caserta </wicri:regionArea><wicri:noRegion>I-81100 Caserta </wicri:noRegion></affiliation></author><author><name sortKey="Iglesias, Rosario" sort="Iglesias, Rosario" uniqKey="Iglesias R" first="Rosario" last="Iglesias">Rosario Iglesias</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biochemistry and Molecular Biology and Physiology, Faculty of Sciences , University of Valladolid , E-47011 Valladolid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Biochemistry and Molecular Biology and Physiology, Faculty of Sciences , University of Valladolid , E-47011 Valladolid </wicri:regionArea><placeName><region nuts="2" type="communauté">Castille-et-León</region></placeName></affiliation></author></analytic><series><title level="j">ACS chemical biology</title><idno type="eISSN">1554-8937</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Agrocybe (chemistry)</term><term>Anti-Infective Agents (pharmacology)</term><term>Cell Line, Tumor (MeSH)</term><term>Cell Proliferation (drug effects)</term><term>Cytotoxins (pharmacology)</term><term>Drug Screening Assays, Antitumor (MeSH)</term><term>Humans (MeSH)</term><term>Microbial Sensitivity Tests (MeSH)</term><term>Micrococcus (drug effects)</term><term>Ribonucleases (isolation & purification)</term><term>Ribonucleases (pharmacology)</term><term>Tobacco Mosaic Virus (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Agrocybe (composition chimique)</term><term>Anti-infectieux (pharmacologie)</term><term>Cytotoxines (pharmacologie)</term><term>Humains (MeSH)</term><term>Lignée cellulaire tumorale (MeSH)</term><term>Micrococcus (effets des médicaments et des substances chimiques)</term><term>Prolifération cellulaire (effets des médicaments et des substances chimiques)</term><term>Ribonucléases (isolement et purification)</term><term>Ribonucléases (pharmacologie)</term><term>Tests de criblage d'agents antitumoraux (MeSH)</term><term>Tests de sensibilité microbienne (MeSH)</term><term>Virus de la mosaïque du tabac (effets des médicaments et des substances chimiques)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Ribonucleases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Infective Agents</term><term>Cytotoxins</term><term>Ribonucleases</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Agrocybe</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Agrocybe</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Proliferation</term><term>Micrococcus</term><term>Tobacco Mosaic Virus</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Micrococcus</term><term>Prolifération cellulaire</term><term>Virus de la mosaïque du tabac</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Ribonucléases</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Anti-infectieux</term><term>Cytotoxines</term><term>Ribonucléases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line, Tumor</term><term>Drug Screening Assays, Antitumor</term><term>Humans</term><term>Microbial Sensitivity Tests</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Tests de criblage d'agents antitumoraux</term><term>Tests de sensibilité microbienne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Ribotoxins make up a group of extracellular rRNA endoribonucleases produced by ascomycetes that display cytotoxicity toward animal cells, having been proposed as insecticidal agents. Recently, the ribotoxin Ageritin has been isolated from the basidiomycetes Agrocybe aegerita (poplar mushroom), suggesting that ribotoxins are widely distributed among fungi. To gain insights into the protective properties of Ageritin against pathogens and its putative biotechnological applications, we have tested several biological activities of Ageritin, comparing them with those of the well-known ribotoxin α-sarcin, and we found that Ageritin displayed, in addition to the already reported activities, (i) antibacterial activity against Micrococcus lysodeikticus, (ii) activity against the tobacco mosaic virus RNA, (iii) endonuclease activity against a supercoiled plasmid, (iv) nuclease activity against genomic DNA, (v) cytotoxicity to COLO 320, HeLa, and Raji cells by promoting apoptosis, and (vi) antifungal activity against the green mold Penicillium digitatum. Therefore, Ageritin and α-sarcin can induce resistance not only to insects but also to viruses, bacteria, and fungi. The multiple biological activities of Ageritin could be exploited to improve resistance to different pathogens by engineering transgenic plants. Furthermore, the induction of cell death by different mechanisms turns these ribotoxins into useful tools for cancer therapy.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31136705</PMID><DateCompleted><Year>2020</Year><Month>02</Month><Day>14</Day></DateCompleted><DateRevised><Year>2020</Year><Month>02</Month><Day>14</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1554-8937</ISSN><JournalIssue CitedMedium="Internet"><Volume>14</Volume><Issue>6</Issue><PubDate><Year>2019</Year><Month>06</Month><Day>21</Day></PubDate></JournalIssue><Title>ACS chemical biology</Title><ISOAbbreviation>ACS Chem Biol</ISOAbbreviation></Journal><ArticleTitle>Ageritin, a Ribotoxin from Poplar Mushroom ( Agrocybe aegerita) with Defensive and Antiproliferative Activities.</ArticleTitle><Pagination><MedlinePgn>1319-1327</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1021/acschembio.9b00291</ELocationID><Abstract><AbstractText>Ribotoxins make up a group of extracellular rRNA endoribonucleases produced by ascomycetes that display cytotoxicity toward animal cells, having been proposed as insecticidal agents. Recently, the ribotoxin Ageritin has been isolated from the basidiomycetes Agrocybe aegerita (poplar mushroom), suggesting that ribotoxins are widely distributed among fungi. To gain insights into the protective properties of Ageritin against pathogens and its putative biotechnological applications, we have tested several biological activities of Ageritin, comparing them with those of the well-known ribotoxin α-sarcin, and we found that Ageritin displayed, in addition to the already reported activities, (i) antibacterial activity against Micrococcus lysodeikticus, (ii) activity against the tobacco mosaic virus RNA, (iii) endonuclease activity against a supercoiled plasmid, (iv) nuclease activity against genomic DNA, (v) cytotoxicity to COLO 320, HeLa, and Raji cells by promoting apoptosis, and (vi) antifungal activity against the green mold Penicillium digitatum. Therefore, Ageritin and α-sarcin can induce resistance not only to insects but also to viruses, bacteria, and fungi. The multiple biological activities of Ageritin could be exploited to improve resistance to different pathogens by engineering transgenic plants. Furthermore, the induction of cell death by different mechanisms turns these ribotoxins into useful tools for cancer therapy.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Citores</LastName><ForeName>Lucía</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology and Physiology, Faculty of Sciences , University of Valladolid , E-47011 Valladolid , Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ragucci</LastName><ForeName>Sara</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Environmental, Biological and Pharmaceutical Sciences and Technologies , University of Campania "Luigi Vanvitelli" , I-81100 Caserta , Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferreras</LastName><ForeName>José M</ForeName><Initials>JM</Initials><Identifier Source="ORCID">0000-0003-4816-5878</Identifier><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology and Physiology, Faculty of Sciences , University of Valladolid , E-47011 Valladolid , Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Di Maro</LastName><ForeName>Antimo</ForeName><Initials>A</Initials><Identifier Source="ORCID">0000-0002-9595-9665</Identifier><AffiliationInfo><Affiliation>Department of Environmental, Biological and Pharmaceutical Sciences and Technologies , University of Campania "Luigi Vanvitelli" , I-81100 Caserta , Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Iglesias</LastName><ForeName>Rosario</ForeName><Initials>R</Initials><Identifier Source="ORCID">0000-0002-5021-1733</Identifier><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology and Physiology, Faculty of Sciences , University of Valladolid , E-47011 Valladolid , Spain.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>06</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>ACS Chem Biol</MedlineTA><NlmUniqueID>101282906</NlmUniqueID><ISSNLinking>1554-8929</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000890">Anti-Infective Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003603">Cytotoxins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.1.-</RegistryNumber><NameOfSubstance UI="D012260">Ribonucleases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.1.-</RegistryNumber><NameOfSubstance UI="C000632196">ageritin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D055362" MajorTopicYN="N">Agrocybe</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000890" MajorTopicYN="N">Anti-Infective Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003603" MajorTopicYN="N">Cytotoxins</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004354" MajorTopicYN="N">Drug 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last="Ferreras">José M. Ferreras</name><name sortKey="Iglesias, Rosario" sort="Iglesias, Rosario" uniqKey="Iglesias R" first="Rosario" last="Iglesias">Rosario Iglesias</name></country><country name="Italie"><noRegion><name sortKey="Ragucci, Sara" sort="Ragucci, Sara" uniqKey="Ragucci S" first="Sara" last="Ragucci">Sara Ragucci</name></noRegion><name sortKey="Di Maro, Antimo" sort="Di Maro, Antimo" uniqKey="Di Maro A" first="Antimo" last="Di Maro">Antimo Di Maro</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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